RAF Typhoon fighter aircraft have conducted a mission with French aircraft in a combined operation targeting an hidden munitions depot in Syria operated by the IS group, per a report from the UK Ministry of Defence.
The location, identified by intelligence, was thought to be housing weapons and explosive materials, the statement said, and was situated in hills just north of Palmyra in central Syria.
"The RAF jets utilized laser-guided Paveway IV weapons to hit a series of access tunnels leading to the depot... early reports indicate the strike was effective," officials stated.
There was no sign of any harm to civilians in the attack late on Saturday and all the aircraft returned safely, the MoD added.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as the so-called Islamic State - imposed extremist governance over large swathes of both Syria and Iraq until 2019.
"This operation demonstrates the UK's leading role, and determination to operate in unison with our allies, to eliminate any revival of the terrorist group and their violent and radical beliefs in the Middle East," UK Defence Secretary the minister said.
RAF aircraft have carried out patrols over Syria to "deter any attempted resurgence" of the group following its routing at the battle of Baghuz in the year 2019, the MoD reported.
"I extend gratitude to all the members of British forces who took part in this strike for their expertise and their valour," Healey said. "They were among thousands of British troops on duty over Christmas and New Year. This mission, to eliminate terrorist threats who endanger our safety, highlights how UK forces are ready to step up, continuously, keeping Britain secure at home and powerful internationally."
During December, the US military carried out what it described as a "large-scale strike" targeting IS targets in the country, subsequent to an assault killed two US servicemembers and a local interpreter in Palmyra.
The United Nations says Islamic State still has between 5,000 and 7,000 fighters in Iraq and Syria.